As the 2025 NFL regular season draws to a close, Week 16 promises critical matchups that could significantly impact the playoff race. Some teams, such as the San Francisco 49ers and New England Patriots, find themselves in win-and-in situations, adding intensity and excitement to an already thrilling weekend of football.
To aid fans and bettors alike, CBS Sports has compiled a comprehensive overview of the best betting picks and expert analysis for this week. With insights from leading NFL analysts and the SportsLine Projection Model, fans can make informed decisions about their wagers.
Starting with the Eagles vs. Commanders matchup on Saturday at 5 p.m. on Fox, the Eagles are favored by 5.5 points after a solid victory against the Raiders. CBS Sports Senior NFL analyst Pete Prisco believes Philadelphia will cover the spread, citing the Commanders’ defensive struggles throughout the season.
The rivalry game between the Packers and Bears unfolds later that evening, with the Bears favored by 1.5 points. Tyler Sullivan from CBS Sports notes the Bears’ quarterback advantages at home and the Packers’ poor defensive performance away from Lambeau, predicting a close win for Chicago.
On Sunday, the Bills take on the Browns at 1 p.m., with Buffalo heavily favored by 10 points. Coming off a significant road win against the Patriots, Prisco expects the Bills to maintain momentum against a struggling Cleveland team.
In an intriguing matchup between the Bengals and Dolphins, both teams have been eliminated from playoff contention, leading Prisco to predict a Miami upset at home. Meanwhile, the Chiefs hope to find success against the Titans despite being eliminated from postseason possibilities and missing star quarterback Patrick Mahomes.
The Chargers are looking to disrupt the Cowboys at 1 p.m. as well, facing a slight point spread in favor of Dallas. CBS analyst Jared Dubin questions why the Cowboys are favored, given their recent struggles.
The Steelers face off against the Lions, with Detroit favored by seven points. Dubin emphasizes the Lions’ offensive prowess compared to a faltering Steelers squad, anticipating a high-scoring affair in favor of Detroit.
Sunday night features a pivotal game between the Ravens and the Patriots, with Baltimore favored by three points. Both teams are battling for their playoff lives, and the Ravens’ weak red-zone performance could be addressed against New England’s struggling defense, according to analyst John Breech.
Wrapping up the week is a Monday night matchup between the 49ers and Colts. The 49ers are favored by 6.5 points, with CBS Sports’ Jordan Dajani noting the team’s strong offensive lineup, which has shown remarkable consistency in recent weeks.
With so much on the line during this thrilling Week 16, fans can expect intense competition across the league. Each game will not only provide entertainment but could also reshape the playoff landscape as teams vie for a shot at the championship.