Iowa State, currently ranked No. 16 in the AP Top 25, is set to face Mississippi State in Sioux Falls, South Dakota, on November 10, 2025. This matchup marks Iowa State’s first non-conference game at the Sanford Pentagon since they defeated Colorado in 2015.
Opening their 2025-26 season with impressive back-to-back victories over Fairleigh Dickinson and Grambling State, Iowa State showcased their offensive prowess by winning both games with an average margin of 39 points—the second-largest in the history of the program under head coach T.J. Otzelberger. In their most recent win, they overwhelmed Grambling State, signaling a promising start to their season.
Mississippi State’s Bulldogs, fresh off a solid 86-63 home victory against North Alabama, will also seek to build momentum in this matchup. After a close first half, the Bulldogs showcased their strength in the second half, outscoring their opponent by 23 points.
Iowa State’s strong start is underscored by the continued recognition of its players, with three Cyclones earning spots on the Naismith Starting Five Preseason Watch lists. This closely matches the achievement of their women’s team, as Iowa State is one of only five schools nationally to have six combined selections on both sides. Notable mentions include Tamin Lipsey, on the Bob Cousy Point Guard of the Year Watch List, and Milan Momcilovic, who had a standout performance with a career-high 29 points in the game against FDU, including seven three-pointers.
Under Coach Otzelberger, Iowa State has an impressive 50-10 record against non-conference opponents, showcasing his capability to guide the team through tough matchups effectively. Additionally, his leadership has resulted in the most NCAA Tournament wins in program history, reflecting a deep-seated winning culture within the team.
This matchup promises to be a thrilling contest, as both squads strive to build on their early-season successes. With Iowa State’s strong track record and Mississippi State keen to assert themselves, fans can expect an engaging game at the Sanford Pentagon.