The Old Dominion Monarchs will take on the South Florida Bulls in the 2025 Cure Bowl this Wednesday. Both teams enter the matchup with strong finishes to their regular seasons; Old Dominion concluded with five straight victories, while South Florida secured wins in two of their last three matches. The Monarchs, with a record of 9-3, finished second in the Sun Belt East Division with a conference record of 6-2, outscoring their opponents by a total of 161 points this season. Meanwhile, the Bulls, also at 9-3, tied for fourth in the American Conference and demonstrated a notable offensive performance, outscoring their rivals by 236 points throughout 2025.
Notably, the game will see both teams without their starting quarterbacks, as Byrum Brown of South Florida and Colton Joseph of Old Dominion have opted out. Compounding matters for the Bulls, head coach Alex Golesh, along with a majority of the offensive staff, will not coach after Golesh accepted a position at Auburn.
Kickoff is set for 5 p.m. ET at Camping World Stadium in Orlando, Florida. In terms of betting lines, the Bulls are favored by 4 points, and the over/under for the total points scored has shifted to 52.5, a decrease of three points from the opener. Many sports analysts encourage reviewing college football predictions before making any bets.
Recent predictions from an advanced modeling system indicate a likely high-scoring game, as the model forecasts that Old Dominion’s running back Trequan Jones could surpass 80 rushing yards and score, while South Florida’s running back trio of Nykahi Davenport, Sam Franklin, and Alvon Isaac may collectively rush for over 100 yards. The model suggests that the game will see a combined total of 56 points, making the over a promising bet in more than 50% of simulations.
With anticipation building for the matchup, this game presents both teams with the chance to showcase their resilience and skill, even amid significant roster changes. Fans and bettors alike will be keen to see how the teams perform in this pivotal bowl game.