Resident Evil: Requiem is packed with secrets for players to discover, and among them are several safes that can significantly enhance your gameplay experience. Players can find safes across various locations, each containing valuable items and resources necessary for survival throughout the game.

In the Rhodes Hill Care Center, four safes are hidden, while two more can be uncovered in the later ARK laboratory sections. Each safe requires a specific code to open, and it is crucial to follow the direction of the lock rotation along with the numerical combination to unlock them successfully.

The first notable safe appears in the Bar & Lounge area. To unlock it, players need to turn the lock left (clockwise) to 10, then right (counterclockwise) to 80, and left to 30. Opening this safe yields three Antique Coins and provides access to Grace’s S&S M232 pistol that can be found nearby.

Next is the Examination Room safe. The combination here entails turning the lock right (counterclockwise) to 30, left (clockwise) to 10, and right to 50. Players who manage to unlock this safe will also be rewarded with three Antique Coins, allowing for further upgrades for Grace.

Another safe can be found in the Waiting Room behind the desk, though it appears to be already unlocked and contains just two Antique Coins—perhaps a sign of prior looting.

Once you acquire a Joint Plug and navigate to the forklift room in the Basement, players can discover the Furnace safe. The code is turned counterclockwise to 60, clockwise to 40, and finally counterclockwise to 80. This safe holds the Raccoon Roundup Map (Rhodes Hill), marking all Mr. Raccoon statues within the Care Center, plus ten Handgun Ammo rounds.

In the ARK’s Sterilization Chamber, which is filled with Lickers, a safe can be found at the back. The code for this safe requires turning the lock counterclockwise to 10, then clockwise to 90, and right to 20. Inside, valuable supplies such as a Med Injector, 15 Handgun Ammo rounds, and a Molotov Cocktail are waiting for players to collect.

Another secure area is the Monitor Control Room, near the Lobby that needs two orbs to unlock. The code consists of turning the lock left to 50, right to 60, and left to 80. Players will find a Med Injector, a Bottle of Acid, and an Empty Bottle within.

For those playing in Insanity mode, the safe locations remain unchanged, but the combinations do differ. Key safe codes for this mode include altered combinations for the Bar & Lounge and Examination Room safes, while others remain either empty or already opened.

By deciphering these codes and unlocking the safes, players can obtain essential items for their exploration and survival, enhancing their overall experience in Resident Evil: Requiem. The game not only offers thrills but also a rewarding journey full of surprises and necessary gear.

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